A war for supremacy has broken out in Marvel's New York between a demonic energy corporation and an army of high-tech armed criminals. Miles, whose home is at the center of this conflict, must learn the cost of being a hero and decide what he must sacrifice for the greater good.

Miles Morales is the youngest Spider-Man in Marvel's New York. After the tragic death of his father, Miles met Peter Parker, who quickly became his friend and mentor. When a genetically mutated spider from Oscorp bit Miles, he developed unique powers - and after months of intense training - Peter agreed to train him.

Miles begins a new chapter in his life in East Harlem, where he faces a whirlwind of new responsibilities: not to ruin his friendships, to have a political voice in his family, and to balance home life with the life of a hero. As a power struggle threatens to destroy the city, he must take on the role of Spider-Man and make it his own, or else everything could be lost.

Parker is the original Spider-Man and mentor to Morales. After the traumatic death of Miles' father, Peter arranges for Miles to start volunteering at F.E.A.S.T., starting a chain of events that would give him powers comparable to his own. Since then, Peter reluctantly agreed to take Miles under his protection as the new superhero, helping the young hero learn to control his powers and giving him whatever advice he can for life itself. As Peter goes abroad with MJ to cover the Simcarian Peace Talks for the Daily Bugle, he will trust Miles to serve the city as the one and only Spider-Man until he returns.